A Subset of Human Uterine Endometrial Macrophages is Alternatively Activated
نویسندگان
چکیده
منابع مشابه
Alternatively activated macrophages in infection and autoimmunity.
Macrophages are innate immune cells that play an important role in activation of the immune response and wound healing. Pathogens that require T helper-type 2 (Th2) responses for effective clearance, such as parasitic worms, are strong inducers of alternatively activated or M2 macrophages. However, infections such as bacteria and viruses that require Th1-type responses may induce M2 as a strate...
متن کامل[Alternatively activated macrophages in helminth infections].
Macrophages not only initiate and modulate immune responses, but also are the final effector cells. Recent studies suggested that macrophages conventionally associated with IFN-gamma dominant Th1-type responses and also playing an essential role in the Th2-type inflammatory response, exhibit a quite different activation from the classically activated macrophages (CAM Phi) stimulated during Th1-...
متن کاملMacrophages in malignant pleural effusions – alternatively activated tumor associated macrophages
Pleural macrophages are involved in local defense mechanisms against environmental pollution, bacteria and cancer. Their main function encompasses phagocytosis of degenerated mesothelial cells. In human pleural effusions macrophages represent more than half of all cells. A model of polarized macrophage activation (M1 and M2) was proposed, which defines a functionally different macrophage popula...
متن کاملAlternatively Activated (M2) Macrophage Phenotype Is Inducible by Endothelin-1 in Cultured Human Macrophages
BACKGROUND Alternatively activated (M2) macrophages are phenotypically characterized by the expression of specific markers, mainly macrophage scavenger receptors (CD204 and CD163) and mannose receptor-1 (CD206), and participate in the fibrotic process by over-producing pro-fibrotic molecules, such as transforming growth factor-beta1 (TGFbeta1) and metalloproteinase (MMP)-9. Endothelin-1 (ET-1) ...
متن کاملCorrection: Alternatively Activated (M2) Macrophage Phenotype Is Inducible by Endothelin-1 in Cultured Human Macrophages
[This corrects the article DOI: 10.1371/journal.pone.0166433.].
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ژورنال
عنوان ژورنال: American Journal of Reproductive Immunology
سال: 2012
ISSN: 1046-7408
DOI: 10.1111/j.1600-0897.2012.01181.x